INTERNATIONAL GUIDELINES

As of January 2023, two sets of international, peer-reviewed treatment guidelines for PANS and PANDAS have been published. These are Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome (Parts I, II, and III, 2017) and Clinical guidance for diagnosis and management of suspected Pediatric Acute-onset Neuropsychiatric Syndrome in the Nordic countries (2021).

JCAP - Clinical Management of PANS:

Part 1 - Psychiatric and Behavioural Interventions- Click here

Thienemann, M., Murphy, T., Leckman, J., Shaw, R., Williams, K., Kapphahn, C., Frankovich, J., Geller, D., Bernstein, G., Chang, K., Elia, J., Swedo, S. (2017) Journal of Child and Adolescent Psychopharmacology. V27(7) pp1-8

Part 2 - Use of Immunomodulatory Therapies - Click here

Frankovich, J., Swedo, S., Murphy, T., Dale, R. C., Agalliu, D., Williams, K., Daines, M., Hornig, M., Chugani, H., Sanger, T., Muscal, E., Pasternack, M., Cooperstock, M., Gans, H., Zhang, Y., Cunningham, M., Bernstein, G., Bromberg, R., Willett, T., Brown, K., Farhadian, B., Chang,K., Geller, D., Hernandez, J., Sherr, J., Shaw, R., Latimer, E., Leckman, J., Thienemann, M., PANS PANDAS Consortium (2017) Journal of Child and Adolescent Psychopharmacology. V27(7) pp1-16

Part 3 - Treatment and Prevention of Infection - Click here

Cooperstock, M., Swedo, S., Pasternack, M., Murphy, T.; for the PANS PANDAS Consortium (2017) Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Journal of Child and Adolescent Psychopharmacology. V27(7) pp1-13

Nordic Guidelines:

Clinical guidance for diagnosis and management of PANS in the Nordic Countries - Click here

Pfeiffer, H., Wickstrom, R., Skov, L., Sørensen, C., Sandvig, I., Gjone, I., Ygberg, S., de Visscher, C., Nordstrom, S., Herner, L., Hesselmark, E., Hedderly, T., Lim, M., Debes, N., Acta Paediatrica. 2021;110:3153–3160.

The PANS PANDAS Working Group does not recommend any particular guidelines. However, in the absence of NICE guidelines, if patients want to share the existing international peer-reviewed guidelines with their doctors for them to use at their discretion, they may do so, however there is no current requirement for doctors to follow them.